Subscribe

A New Perspective on Cellular Aging

In this episode of the Ayık Kafa podcast, Dr. Sandra Kaufmann, MD. In this 2nd part of our 2-part podcast series, she discusses her unique approach to longevity and aging, emphasizing the importance of cellular health.

Dr. Kaufmann is an award-winning physician who specialized in pediatric anesthesia at Johns Hopkins, served as Chief of Pediatric Anesthesia at Joe DiMaggio Children’s Hospital, and founded The Kaufmann Anti-Aging Institute, where she developed a comprehensive theory of aging science. She shares her theories on aging, “The 7 Tenets” of cellular decline, and the significance of DNA repair and epigenetics.

Share this podcast

In this Episode of Ayık Kafa

Last week, we covered the first 3 principles of the Seven Tenets. In this episode, we complete the set: Tenet 4 is Quality Control: how cells repair damaged DNA and proteins, and clean up waste through autophagy. Tenet 5 is Immune Balance: why a bad immune system increases the risk of chronic inflammation, infections, and cancer. Tenet 6 is Cellular Characteristics: each cell type, like brain, bone, or skin, has its own lifespan and nutritional needs. And Tenet 7 is Waste Management: how advanced glycation end products (AGEs), the sugar-related junk, are stopped and cells kept clear. The podcast concludes with a focus on glycation and its detrimental effects on health, highlighting the need for effective waste management in the body. She discusses various aspects of health, longevity, and the role of supplements and pharmaceuticals in maintaining well-being. She highlights the critical role of sirtuins in cellular health and longevity, the importance of sleep and circadian rhythms, and the interaction between AMP kinase and mTOR in energy regulation. She emphasizes the importance of understanding the mechanisms behind aging and how to mitigate damage through lifestyle choices and targeted interventions. The discussion covers topics such as trans-glycosylating agents, the impact of diet soda, navigating toxins in modern life, the use of GLP-1 agonists, and her unique approach to supplement recommendations through the Kaufmann rating system. She shares her personal experiences with medications and supplements, highlighting the importance of a multifactorial approach to health.

00:00-04:30 The Role of Inflammation in Aging
04:30-07:31 Inflammation and its management
07:31-12:02 Cellular health and stem cells
12:02-16:49 Senescent Cells: The Grumpy Old Man Cells
16:49-19:02 Protocols for senescent cells
19:02-23:55 Stem Cells: The controversy
23:55-32:34 Waste management: Glycation and Lipofusion
32:34-33:39 Understanding Trans-Glycosylating agents
33:39-35:10 The Role of Diet Coke in health
35:10-36:15 Navigating Toxins in Modern Life
36:15-38:17 Exploring GLP-1 Agonists
38:17-39:39 The Panacea Approach to Supplements
39:39-41:33 Pharmaceuticals vs. Supplements
41:33-45:22 Repurposing Medications for Longevity
45:22-51:02 The Kaufmann Rating System for Supplements
51:02-52:19 Lifestyle Recommendations for Longevity
52:19-54:07 Favorite Supplements and Medications
54:07-55:01 Accessing Exosome Treatments
55:01-59:28 Final thoughts and wrap up

Dr. Sandra Kaufmann, MD:
Website: https://kaufmannprotocol.com/bio
Instagram:
https://www.instagram.com/kaufmannlongevity/

*Collaborations & Sponsors:

https://dotshub.com/

Special thanks to T.C. Istanbul Gedik University
https://www.gedik.edu.tr/en/

Disclaimer
The information and statements on our website are not intended to guide individuals towards medical diagnosis and treatment. Please consult with your doctor for medical diagnostic and treatment procedures. The contents are shared for informational purposes only, derived from scientific studies prepared by EMC Medya Yayıncılık Ticaret Ltd. Şti.’s researchers, consultants, and authors/scientists, as well as compilations from publicly available publications. Our texts do not contain health statements related to medical diagnosis or treatment

Subscribe to Longevilab​

Subscribe to our newsletter and stay updated.

Subscribe to Longevilab​

Subscribe to our newsletter and stay updated.

*